Endocrine Abstracts

Introduction: The purpose of this study was to evaluate and compare disease outcomes in patients with acromegaly receiving first-line and second-line (after transphenoidal surgery) somatostatin analogs (SSA) treatment.Methods: The study involved retrospective data collection from charts of 49 patients with acromegaly who were consulted by an endocrinologist in Vilnius University Hospital Santariskiu klinikos between 2007 and 2013.R...

Introduction: The purpose of this study was to characterize management and outcomes of patients with acromegaly seen in single centre in Lithuania.Methods: The study involved retrospective data collection from charts of 44 patients who were admitted to the centre between 2007 and 2012.Results: All cases except one were caused by pituitary adenomas (61.4% macroadenomas, and 29.5% microadenomas). The most common co-morbidities were n...

Dehydroepiandrosterone sulfate (DHEAS) is a sulfated ester of dehydroepiandrosterone. Studies of large number of males with DHEAS pathology are infrequent.Objective: To perform an investigation of significance of DHEAS assessment in males of different ages.Subjects. Methods. ResultsWe analyzed clinical data of 3533 patient’s (3013 females and 520 males) from DHEAS assessment lists of Vilnius and Kaunas ...

Background: Incidental macroprolactinoma is an unsuspected prolactin-secreting pituitary adenoma larger than 1 cm that is discovered by an imaging test performed for an unrelated reason.Case presentation: A 25-year-old man was diagnosed with incidental macroprolactinoma (30.3×23.4×22.6 mm) following a head MRI scan after trauma. At the initial investigation, the patient had no complaints and denied any sexual dysfunction. Physical examination s...

Objective: To determine the long-term effect of weight loss on arterial function parameters in morbidly obese patients who underwent laparoscopic adjustable gastric banding (LAGB).Subjects: Forty-eight Caucasian subjects mean age 47.38±10.77 years and 32 (66.67%) were female with morbid obesity who underwent LAGB and completed 4 years follow-up.Measurements: Patients were evaluated at baseline, 1 year and 4 years after LAGB fo...

Recently we described clinical case of 38-year-old fertile woman with sudden onset of a multiple clinical symptoms: weight gain, secondary amenorrhea, hirsutism and seizures. Adrenal tumour co-secreted high amounts of DHEA sulfate, testosterone (T) and aldosterone (A) (Matulevicius et al. 2014). The symptoms of the disease disappeared after laparoscopic removal of adrenal tumour, which proved to be an adrenocortical oncocytoma. A hypersecretion of A remained after res...

Sexual dysfunction of type 1 diabetic (T1D) men is an area that has been rarely investigated until now. Investigation of reproductive health of young men was performed in Nordic and Baltic countries in 2003/2004 (‘The Reproductive function of Estonian, Latvian and Lithuanian young men’ (ELLY)) but analysis of sexual function was out of the target of the study. In this study we invited those presumably healthy men to participate as controls for investigation of T1D me...

Introduction: Androgen secreting adrenal tumours are rare and sometimes malignant.We report hormonal and sexual changes in 39-year-old woman with androgen secreting adrenal tumour completely healed by resection of the tumour.Case report: Androgen secreting adrenal tumour that manifested in 39-year-old woman with suddenly appeared amenorrhea, weight gain, hirsutism, epileptic seizures and elevated DHEA-S and testosterone is describe...

Relation of dehydroepiandrosterone sulphate (DHEAS) concentration and adrenal tumors (AT) has never been investigated systematically. After promising Terzolo group (1995, 1996, 2000) investigations, there was made a recommendation in the last clinical guidelines for adrenal incidentaloma (2016) to assess concentration of DHEAS in special clinical situations. Here we present the first systemic study of DHEAS in adrenal tumors.The aim was to analyse the cl...

The 1772 patients were referred for the dehydroepiandrosterone sulphate (DHEA-S) concentration assessment in Lithuania during 2014. We investigated 309 clinical history cases of which 162 presented with normal DHEA-S concentration and 147 with elevated one.One hundred twenty-three women with increased DHEA-S were examined. The following symptoms were found: hirsutism −39%, menstruation disorders −23%, weight gain −8%, and the rest &#872...